Wilson Wolf
SMART G-Rex®
Benchtop Platform
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Expected Launch: Q1 2026
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Beta Testing: Click here
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Partner: Wilson Wolf
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Vessel: G-Rex 100M​
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Product Overview​
G-Rex® is the market leader in cell and gene therapy production due to its scalability, simplicity, and reliability. In partnership with Wilson Wolf Manufacturing LLC, Skroot has developed a SMART G-Rex® that can track cell progression without any sampling. The vessel is simply placed on a benchtop reader, scanned and growth level is reported. The tracked growth can indicate harvest time, level of cell production, and aberrant runs. Learn more below.
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​Product Highlights
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Eliminates the need for manual sampling. Scans can be completed in under 30 seconds and do not require a biosafety cabinet
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Provides users with a "Ready, Not Ready" indicator allowing the operator to quickly screen what vessels to harvest
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Software compliance: 21 CFR Part 11 compliant
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Reader compliance: FCC, UL, REACH, RoHS, CE (pending)
SMART Sensor
SMART sensors are integrated into the G-Rex® during production and undergo the same sterilization procedure. The sensor does not change standard G-Rex® operating procedures.
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The SMART sensor leverages a selective transduction membrane that softens when it is exposed to secreted metabolites that present in cell growth (see right). As the transduction membrane softens the sensor response changes. Read more in our publications.
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Reader
The benchtop reader includes an adapter plate for the specific G-Rex® size (currently G100M only). The operator slides the G-Rex® into the keyed adapter and hits scan to perform the measurement. Barcode stickers and a scanner are included for enhanced chain of identity protocols or the user can manually enter printed ID numbers from their own inventory system.
Software
The benchtop reader includes a touch user interface that completes each sensor scan and tracks cell growth extent for each vessel. This is reported as the Skroot Growth Index (SGI) which can be calibrated to cell count of a specific cell type. In most use cases the SGI is sufficient to track the growth phases and identify when the cells are ready to harvest. The growth report is stored on the reader and batches of reports can be exported via USB drive on demand.
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Harvest Indicator
The benchtop reader provides users with an optional harvest indicator feature. The user can specify the desired growth threshold (SGI) and rate of growth (dSGI) at which the unit signals to operators when the cells have slowed in growth and are ready to harvest.