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Technology

SMART Platform

The Single-use, Metabolite Absorbing, Resonant Transducer (SMART) Platform consists of a reader, SMART sensor, and computer interface with customizable software. The sensor is integrated with world-class partners into market-leading vessels. Users can track progress of cell-growth without intervention by placing on a benchtop reader for periodic measurements or on a continuous reader for real-time tracking. The cell growth progress can be monitored remotely on a secure dashboard from any internet enabled device. It is as simple as these four steps:

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Open Sterile Packaging

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Place Vessel on Reader

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Scan Sensor with Reader

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Stream Progress of Cells

The SMART sensor arrives pre-applied and gamma sterilized on the vessel. During cell growth, the sensor membrane absorbs a class of secondary metabolites that tracks active cell progression. The passive (no-battery) sensor stores this information and is scanned frequently by the external reader to provide minute-by-minute tracking of growth. â€‹More information on can be found in the following publications:

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Publications

  1. Single-Use, Metabolite Absorbing, Resonant Transducer (SMART) Culture Vessels for Label-Free, Continuous Cell Culture Progression Monitoring​

  2. SMART Sensors for Cell Growth Monitoring in Closed System G-Rex for Scalable, Cost-Conscious Cell and Gene Therapy Manufacturing

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Advantages 

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Modular: Compatible across a wide range of popular single and multi-use cell culture vessels. The sensor has also been validated across cell types, including mammalian, insect, and bacterial.

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Continuous: Generates minute-by-minute data. Allows for monitoring of changes in growth rate.

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Eliminate Sampling: SMART vessels eliminate need for complex operation of sampling during the run; no extra consumables and instruments needed to track growth; eliminates risk of contamination from sampling event.

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Inexpensive: Skroot SMART stickers are low cost, making them ideal for high throughput and single use applications.

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Data Analytics: Provides easy export to *.csv file for further analysis in Excel, Python, MATLAB, etc. Data can also be accessed in the cloud and can be viewed from your phone, tablet, or desktop.

 

Not Optical: No light path needed. Can be used with opaque vessels and in high density cell cultures.

Patents

The SMART platform is protected with the following patents:​​

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  1. Wireless Sensor (US Patent #11105761)

  2. Resonant Sensor Reader (WO Patent #236534)

  3. Transduction Cell Membrane (WO Patent #2021236534)

  4. Tuning Resonant Sensor Dynamic Response to Specific Cell Growth Rates by Adjusting Kerf Size (Patent Pending)

  5. Automated System for Signaling Cell Growth Events Using Continuous Sensor Data (Patent Pending)

  6. Resonant Sensors for Monitoring Therapeutic Cell Growth (Provisional at USPTO)

  7. Radiofrequency Reader Platform for Intermittent or Continuous Noncontact Monitoring and Harvest Optimization of Therapeutic Cells in Closed Vessels (Provisional at USPTO)​​​

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