Skroot Laboratory, Inc., is a seed stage biotechnology company providing wireless process analytical technologies (PAT) for cell and protein therapy development, especially suited for upstream design campaigns. Skroot was founded in 2018 by Dr. Nigel Reuel, and has been supported by NSF Phase I and II SBIR awards and federal CARES act funding.
About Skroot Technology
Most recently, Skroot has developed and deployed a wireless, non-invasive platform that can continually quantify cell concentration, foaming, and temperature in upstream cell vessels and single-use bioreactors (plastic or glass)—without contacting the culture solution and without manual intervention or manipulation. The technology can simultaneously monitor numerous vessels and push alerts to operators for time-critical data points including feed, harvest, and induction points.
With existing technology, changes in solution permittivity are used to track cell growth, but these probes must make product contact; the Skroot platform uses a single-use sensor on the outside of a vessel to sense the same change in permittivity, contact-free, exploiting a resonant structure that modulates frequency during cell growth. This conformable, thin sensor is ideally suited for upstream bioprocessing and aligns with single-use and continuous manufacturing initiatives.
The sensor signal is measured by reusable hardware (a reader) placed proximal to the vessel and sensor with flexible and configurable data save and notification options. The platform is sterile, continuous, and eliminates the need for manual sampling, making real-time cell density measurement a trivial matter. The Skroot platform also enables alignment with continuous manufacturing practices and FDA Industry Guidance for PAT in upstream processes.
About Skroot Technology
Most recently, Skroot has developed and deployed a wireless, non-invasive platform that can continually quantify cell concentration, foaming, and temperature in upstream cell vessels and single-use bioreactors (plastic or glass)—without contacting the culture solution and without manual intervention or manipulation. The technology can simultaneously monitor numerous vessels and push alerts to operators for time-critical data points including feed, harvest, and induction points.
With existing technology, changes in solution permittivity are used to track cell growth, but these probes must make product contact; the Skroot platform uses a single-use sensor on the outside of a vessel to sense the same change in permittivity, contact-free, exploiting a resonant structure that modulates frequency during cell growth. This conformable, thin sensor is ideally suited for upstream bioprocessing and aligns with single-use and continuous manufacturing initiatives.
The sensor signal is measured by reusable hardware (a reader) placed proximal to the vessel and sensor with flexible and configurable data save and notification options. The platform is sterile, continuous, and eliminates the need for manual sampling, making real-time cell density measurement a trivial matter. The Skroot platform also enables alignment with continuous manufacturing practices and FDA Industry Guidance for PAT in upstream processes.
Commercialization
To date Skroot Lab has been awarded over $1.4M in federal grants to bring to market innovative sensors for cell-based biomanufacturing. Initial Beta users have found this technology ideal for improving productivity in upstream process development. Upstream bio-therapeutic process developers can use the Skroot platform to make rigorous models, reduce risk of progressing costly conditions/products, and reduce time to market.
Skroot is now offering Early Adopter/BETA kits on a select basis. These kits are currently in use at major biopharma, agriculture, and food companies to automate cell measurements in upstream processes. Skroot is also currently engaging enterprise level early adopter partners to strategically scale product development and deployment, and to advance continuous manufacturing practices throughout upstream bioprocessing.
Contact Skroot
Please reach out to Skroot Laboratory, Inc., for more information on the company, the technology, and/or commercialization as an early adopter of the Skroot platform.
To date Skroot Lab has been awarded over $1.4M in federal grants to bring to market innovative sensors for cell-based biomanufacturing. Initial Beta users have found this technology ideal for improving productivity in upstream process development. Upstream bio-therapeutic process developers can use the Skroot platform to make rigorous models, reduce risk of progressing costly conditions/products, and reduce time to market.
Skroot is now offering Early Adopter/BETA kits on a select basis. These kits are currently in use at major biopharma, agriculture, and food companies to automate cell measurements in upstream processes. Skroot is also currently engaging enterprise level early adopter partners to strategically scale product development and deployment, and to advance continuous manufacturing practices throughout upstream bioprocessing.
Contact Skroot
Please reach out to Skroot Laboratory, Inc., for more information on the company, the technology, and/or commercialization as an early adopter of the Skroot platform.